Lynch Syndrome-associated Mutations in MSH2 Alter DNA Repair and Checkpoint Response Functions In Vivo

The DNA mismatch repair (MMR) pathway is essential in maintaining genomic stability through its role in DNA repair and the checkpoint response. Loss of DNA MMR underlies the hereditary cancer disease Lynch Syndrome (LS). Germline mutations in MSH2 account for approximately 40% of LS patients and of...

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Hlavní autoři: Mastrocola, Adam S, Heinen, Christopher D
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2010
Témata:
Mutation in Brief
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947597/
https://ncbi.nlm.nih.gov/pubmed/20672385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.21333
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