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Tuberin Regulates E-Cadherin Localization: Implications in Epithelial-Mesenchymal Transition
The tuberous sclerosis complex 2 (TSC2) gene encodes the protein tuberin, which functions as a key negative regulator of both mammalian target of rapamycin (mTOR) C1-dependent cell growth and proliferation. Loss-of-function mutations of TSC2 result in mTORC1 hyperactivity and predispose individuals...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947273/ https://ncbi.nlm.nih.gov/pubmed/20813961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090233 |
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