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Ab initio prediction of mutation-induced cryptic splice-site activation and exon skipping
Mutations that affect splicing of precursor messenger RNAs play a major role in the development of hereditary diseases. Most splicing mutations have been found to eliminate GT or AG dinucleotides that define the 5′ and 3′ ends of introns, leading to exon skipping or cryptic splice-site activation. A...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947103/ https://ncbi.nlm.nih.gov/pubmed/19142208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2008.257 |
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