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Direct DNA Methylation Profiling Using Methyl Binding Domain Proteins
Methylation of DNA is responsible for gene silencing by establishing heterochromatin structure that represses transcription, and studies have shown that cytosine methylation of CpG islands in promoter regions acts as a precursor to early cancer development. The naturally occurring methyl binding dom...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946844/ https://ncbi.nlm.nih.gov/pubmed/20507169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac1010316 |
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