Autoimmunity to Peptidyl Arginine Deiminase Type 4 Precedes Clinical Onset of Rheumatoid Arthritis

OBJECTIVE: To determine if antibodies against peptidyl arginine deiminase Type 4 (PAD-4) are present in the pre-clinical phase of rheumatoid arthritis (RA), and to compare their appearance to other pre-clinical autoantibodies. METHODS: Prediagnosis serum samples from 83 subjects with RA were evaluat...

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Autori principali: Kolfenbach, Jason R., Deane, Kevin D., Derber, Lezlie A., O’Donnell, Colin I., Gilliland, William R., Edison, Jess D., Rosen, Antony, Darrah, Erika, Norris, Jill M., Holers, V. Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946499/
https://ncbi.nlm.nih.gov/pubmed/20496417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27570
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