Association of Cross-Reactive Antibodies Targeting Peptidyl-Arginine Deiminase 3 and 4 with Rheumatoid Arthritis-Associated Interstitial Lung Disease

BACKGROUND: A subset of rheumatoid arthritis (RA) patients have detectable antibodies directed against the peptidyl-arginine deiminase (PAD) enzyme isoforms 3 and 4. Anti-PAD3/4 cross-reactive antibodies (anti-PAD3/4XR) have been shown to lower the calcium threshold required for PAD4 activation, an...

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Detalhes bibliográficos
Main Authors: Giles, Jon T., Darrah, Erika, Danoff, Sonye, Johnson, Cheilonda, Andrade, Felipe, Rosen, Antony, Bathon, Joan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047055/
https://ncbi.nlm.nih.gov/pubmed/24901704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098794
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