Metronomic small molecule inhibitor of Bcl-2 (TW-37) is anti-angiogenic and potentiates the anti-tumor effect of ionizing radiation

PURPOSE: To investigate the effect of a metronomic (low dose, high frequency) small molecule inhibitor of Bcl-2 (TW-37) in combination with radiotherapy on microvascular endothelial cells in vitro and in tumor angiogenesis in vivo. METHODS AND MATERIALS: Primary human dermal microvascular endothelia...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Zeitlin, Benjamin D., Spalding, Aaron C., Campos, Marcia S., Ashimori, Naoki, Dong, Zhihong, Wang, Shaomeng, Lawrence, Theodore S., Nör, Jacques E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946486/
https://ncbi.nlm.nih.gov/pubmed/20675079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2010.04.024
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky