TW-37, a small molecule inhibitor of Bcl-2, mediates S phase cell cycle arrest and suppresses head and neck tumor angiogenesis

Members of the Bcl-2 family play a major role in the pathobiology of head and neck cancer. We have shown that Bcl-2 orchestrates a crosstalk between tumor cells and endothelial cells that have a direct impact on the progression of head and neck squamous cell carcinoma (HNSCC). Notably, Bcl-2 is sign...

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Autori principali: Ashimori, Naoki, Zeitlin, Benjamin D., Zhang, Zhaocheng, Warner, Kristy, Turkienicz, Ilan M., Spalding, Aaron C., Teknos, Theodoros N., Wang, Shaomeng, Nör, Jacques E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709836/
https://ncbi.nlm.nih.gov/pubmed/19372562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1078
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