Metronomic small molecule inhibitor of Bcl-2 (TW-37) is anti-angiogenic and potentiates the anti-tumor effect of ionizing radiation

PURPOSE: To investigate the effect of a metronomic (low dose, high frequency) small molecule inhibitor of Bcl-2 (TW-37) in combination with radiotherapy on microvascular endothelial cells in vitro and in tumor angiogenesis in vivo. METHODS AND MATERIALS: Primary human dermal microvascular endothelia...

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Main Authors: Zeitlin, Benjamin D., Spalding, Aaron C., Campos, Marcia S., Ashimori, Naoki, Dong, Zhihong, Wang, Shaomeng, Lawrence, Theodore S., Nör, Jacques E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946486/
https://ncbi.nlm.nih.gov/pubmed/20675079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2010.04.024
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