PLASMA SPHINGOSINE 1-PHOSPHATE IS A MAJOR CHEMOATTRACTANT THAT DIRECTS EGRESS OF HEMATOPOIETIC STEM PROGENITOR CELLS FROM BONE MARROW AND ITS LEVEL IN PERIPHERAL BLOOD INCREASES DURING MOBILIZATION DUE TO ACTIVATION OF COMPLEMENT CASCADE/MEMBRANE ATTACK COMPLEX

Complement cascade (CC) becomes activated and its cleavage fragments play a crucial role in the mobilization of hematopoietic stem/progenitor cells (HSPCs). Here, we sought to determine which major chemottractant present in peripheral blood (PB) is responsible for the egress of HSPCs from the BM. We...

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Main Authors: Ratajczak, Mariusz Z., Lee, HakMo, Wysoczynski, Marcin, Wan, Wu, Marlicz, Wojciech, Laughlin, Mary J., Kucia, Magda, Janowska-Wieczorek, Anna, Ratajczak, Janina
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946378/
https://ncbi.nlm.nih.gov/pubmed/20357827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.53
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