Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

High-dose methotrexate (HDMTX) is a component of most treatment protocols for childhood acute lymphoblastic leukemia (ALL), yet recent studies of receptor-mediated transport and saturable polyglutamylation have questioned its rationale. To investigate this in vivo, methotrexate and its active polygl...

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Главные авторы: Synold, T W, Relling, M V, Boyett, J M, Rivera, G K, Sandlund, J T, Mahmoud, H, Crist, W M, Pui, C H, Evans, W E
Формат: Artigo
Язык:Inglês
Опубликовано: 1994
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC294625/
https://ncbi.nlm.nih.gov/pubmed/7525652
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