Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.

High-dose methotrexate (HDMTX) is a component of most treatment protocols for childhood acute lymphoblastic leukemia (ALL), yet recent studies of receptor-mediated transport and saturable polyglutamylation have questioned its rationale. To investigate this in vivo, methotrexate and its active polygl...

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Pubblicato in:	J Clin Invest
Autori principali:	Synold, T W, Relling, M V, Boyett, J M, Rivera, G K, Sandlund, J T, Mahmoud, H, Crist, W M, Pui, C H, Evans, W E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294625/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7525652/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117552
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