Targeting ganglioside epitope 3G11 on the surface of CD4(+) T cells suppresses EAE by altering the Treg/T(h)17 cell balance

Loss of expression of the 3G11 epitope, present on disialoceramide that is predominantly found on CD4(+) T cells, has been associated with a regulatory T cell (Treg) phenotype and tolerance induction in experimental autoimmune encephalomyelitis (EAE). Here we report that treatment with anti-3G11 mAb...

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Bibliographic Details
Main Authors: Zhao, Zhao, Ciric, Bogoljub, Yu, Shuo, Zhang, Guang-Xian, Rostami, Abdolmohamad
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
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Original Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946215/
https://ncbi.nlm.nih.gov/pubmed/20679513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxq432
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