CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes

The interleukin-17 (IL-17) cytokine family is crucial to the progression of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). It has been shown in a neuroectoderm-specific knockout study that astrocyte-restricted ablation of Act1, a key and common transcrip...

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Bibliografiske detaljer
Main Authors: Yan, Yaping, Ding, Xiaoli, Li, Ke, Ciric, Bogoljub, Wu, Shuai, Xu, Hui, Gran, Bruno, Rostami, Abdolmohamad, Zhang, Guang-Xian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392982/
https://ncbi.nlm.nih.gov/pubmed/22434134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.12
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