Elevated Cytosolic Na(+) Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes

BACKGROUND: —Oxidative stress is causally linked to the progression of heart failure, and mitochondria are critical sources of reactive oxygen species in failing myocardium. We previously observed that in heart failure, elevated cytosolic Na(+) ([Na(+)](i)) reduces mitochondrial Ca(2+) ([Ca(2+)](m))...

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Hauptverfasser: Kohlhaas, Michael, Liu, Ting, Knopp, Andreas, Zeller, Tanja, Ong, Mei Fang, Böhm, Michael, O'Rourke, Brian, Maack, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946079/
https://ncbi.nlm.nih.gov/pubmed/20351235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.914911
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