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Elevated Cytosolic Na(+) Decreases Mitochondrial Ca(2+) Uptake During Excitation–Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes
Mitochondrial Ca(2+) ([Ca(2+)](m)) regulates oxidative phosphorylation and thus contributes to energy supply and demand matching in cardiac myocytes. Mitochondria take up Ca(2+) via the Ca(2+) uniporter (MCU) and extrude it through the mitochondrial Na(+)/Ca(2+) exchanger (mNCE). It is controversial...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711867/ https://ncbi.nlm.nih.gov/pubmed/16778127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000232546.92777.05 |
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