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Enhancing Mitochondrial Ca(2+) Uptake in Myocytes From Failing Hearts Restores Energy Supply and Demand Matching
Mitochondrial ATP production is continually adjusted to energy demand through coordinated increases in oxidative phosphorylation and NADH production mediated by mitochondrial Ca(2+)([Ca(2+)](m)). Elevated cytosolic Na(+) impairs [Ca(2+)](m) accumulation during rapid pacing of myocytes, resulting in...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711021/ https://ncbi.nlm.nih.gov/pubmed/18599868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.175919 |
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