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Structural Determinants for the Stereoselective Hydrolysis of Chiral Substrates by Phosphotriesterase

Wild-type phosphotriesterase (PTE) preferentially hydrolyzes the R(p)-enantiomers of the nerve agents sarin (GB) and cyclosarin (GF) and their chromophoric analogues. The active site of PTE can be subdivided into three binding pockets that have been denoted as the small, large and leaving group pock...

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Autors principals: Tsai, Ping-Chuan, Fan, Yubo, Kim, Jungwook, Yang, Lijiang, Almo, Steven C., Gao, Yi Qin, Raushel, Frank M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945819/
https://ncbi.nlm.nih.gov/pubmed/20695627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101058z
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