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Structural Determinants for the Stereoselective Hydrolysis of Chiral Substrates by Phosphotriesterase
Wild-type phosphotriesterase (PTE) preferentially hydrolyzes the R(p)-enantiomers of the nerve agents sarin (GB) and cyclosarin (GF) and their chromophoric analogues. The active site of PTE can be subdivided into three binding pockets that have been denoted as the small, large and leaving group pock...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945819/ https://ncbi.nlm.nih.gov/pubmed/20695627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101058z |
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