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Structural Determinants for the Stereoselective Hydrolysis of Chiral Substrates by Phosphotriesterase
Wild-type phosphotriesterase (PTE) preferentially hydrolyzes the R(p)-enantiomers of the nerve agents sarin (GB) and cyclosarin (GF) and their chromophoric analogues. The active site of PTE can be subdivided into three binding pockets that have been denoted as the small, large and leaving group pock...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945819/ https://ncbi.nlm.nih.gov/pubmed/20695627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101058z |
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