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Structural Determinants for the Stereoselective Hydrolysis of Chiral Substrates by Phosphotriesterase

Wild-type phosphotriesterase (PTE) preferentially hydrolyzes the R(p)-enantiomers of the nerve agents sarin (GB) and cyclosarin (GF) and their chromophoric analogues. The active site of PTE can be subdivided into three binding pockets that have been denoted as the small, large and leaving group pock...

詳細記述

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書誌詳細
主要な著者: Tsai, Ping-Chuan, Fan, Yubo, Kim, Jungwook, Yang, Lijiang, Almo, Steven C., Gao, Yi Qin, Raushel, Frank M.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945819/
https://ncbi.nlm.nih.gov/pubmed/20695627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101058z
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