Deciphering the Hidden Informational Content of Protein Sequences: FOLDABILITY OF PROINSULIN HINGES ON A FLEXIBLE ARM THAT IS DISPENSABLE IN THE MATURE HORMONE

Protein sequences encode both structure and foldability. Whereas the interrelationship of sequence and structure has been extensively investigated, the origins of folding efficiency are enigmatic. We demonstrate that the folding of proinsulin requires a flexible N-terminal hydrophobic residue that i...

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Autori principali: Liu, Ming, Hua, Qing-xin, Hu, Shi-Quan, Jia, Wenhua, Yang, Yanwu, Saith, Sunil Evan, Whittaker, Jonathan, Arvan, Peter, Weiss, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945590/
https://ncbi.nlm.nih.gov/pubmed/20663888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.152645
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