Solution Structure of Proinsulin: CONNECTING DOMAIN FLEXIBILITY AND PROHORMONE PROCESSING

The folding of proinsulin, the single-chain precursor of insulin, ensures native disulfide pairing in pancreatic β-cells. Mutations that impair folding cause neonatal diabetes mellitus. Although the classical structure of insulin is well established, proinsulin is refractory to crystallization. Here...

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Detalhes bibliográficos
Main Authors: Yang, Yanwu, Hua, Qing-xin, Liu, Jin, Shimizu, Eri H., Choquette, Meredith H., Mackin, Robert B., Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832934/
https://ncbi.nlm.nih.gov/pubmed/20106974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.084921
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