Solution Structure of Proinsulin: CONNECTING DOMAIN FLEXIBILITY AND PROHORMONE PROCESSING

The folding of proinsulin, the single-chain precursor of insulin, ensures native disulfide pairing in pancreatic β-cells. Mutations that impair folding cause neonatal diabetes mellitus. Although the classical structure of insulin is well established, proinsulin is refractory to crystallization. Here...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yang, Yanwu, Hua, Qing-xin, Liu, Jin, Shimizu, Eri H., Choquette, Meredith H., Mackin, Robert B., Weiss, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832934/
https://ncbi.nlm.nih.gov/pubmed/20106974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C109.084921
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge