The Biological Effects of C/EBPα in K562 Cells Depend on the Potency of the N-terminal Regulatory Region, Not on Specificity of the DNA Binding Domain

The transcription factor C/EBPα is more potent than C/EBPβ in inducing granulocitic differentiation and inhibiting BCR/ABL-expressing cells. We took a “domain swapping” approach to assess biological effects, modulation of gene expression, and binding to C/EBPα-regulated promoters by wild-type and ch...

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Main Authors: Ferrari-Amorotti, Giovanna, Mariani, Samanta Antonella, Novi, Chiara, Cattelani, Sara, Pecorari, Luisa, Corradini, Francesca, Soliera, Angela Rachele, Manzotti, Gloria, Fragliasso, Valentina, Zhang, Ying, Martinez, Robert V., Lam, Eric W.-F., Guerzoni, Clara, Calabretta, Bruno
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945577/
https://ncbi.nlm.nih.gov/pubmed/20659895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128272
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