Monocyte-macrophage differentiation of acute myeloid leukemia cell lines by small molecules identified through interrogation of the Connectivity Map database

The transcription factor C/EBPα is required for granulocytic differentiation of normal myeloid progenitors and is frequently inactivated in acute myeloid leukemia (AML) cells. Ectopic expression of C/EBPα in AML cells suppresses proliferation and induces differentiation suggesting that restoring C/E...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Manzotti, Gloria, Parenti, Sandra, Ferrari-Amorotti, Giovanna, Soliera, Angela Rachele, Cattelani, Sara, Montanari, Monica, Cavalli, Daniel, Ertel, Adam, Grande, Alexis, Calabretta, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614550/
https://ncbi.nlm.nih.gov/pubmed/26102293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1033591
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