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Activation of Phenylalanine Hydroxylase Induces Positive Cooperativity toward the Natural Cofactor
Protein misfolding with loss-of-function of the enzyme phenylalanine hydroxylase (PAH) is the molecular basis of phenylketonuria in many individuals carrying missense mutations in the PAH gene. PAH is complexly regulated by its substrate l-Phenylalanine and its natural cofactor 6R-l-erythro-5,6,7,8-...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945563/ https://ncbi.nlm.nih.gov/pubmed/20667834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.124016 |
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