Loss of Function in Phenylketonuria Is Caused by Impaired Molecular Motions and Conformational Instability

A significant share of patients with phenylalanine hydroxylase (PAH) deficiency benefits from pharmacological doses of tetrahydrobiopterin (BH(4)), the natural PAH cofactor. Phenylketonuria (PKU) is hypothesized to be a conformational disease, with loss of function due to protein destabilization, an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gersting, Søren W., Kemter, Kristina F., Staudigl, Michael, Messing, Dunja D., Danecka, Marta K., Lagler, Florian B., Sommerhoff, Christian P., Roscher, Adelbert A., Muntau, Ania C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443833/
https://ncbi.nlm.nih.gov/pubmed/18538294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.05.013
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados