Potentiation of Temozolomide Cytotoxicity by Polymerase β Inhibition Is Increased in the Absence of BRCA2

Base excision repair (BER) plays a critical role in the repair of bases damaged by oxidative metabolism or alkylating agents, such as those commonly utilized in cancer therapy. Incomplete BER generates intermediates that require activation of homology-dependent DNA repair to resolve. We investigated...

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Библиографические подробности
Главные авторы: Stachelek, Gregory C., Dalal, Shibani, Donigan, Katherine A., Hegan, Denise Campisi, Sweasy, Joann B., Glazer, Peter M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943728/
https://ncbi.nlm.nih.gov/pubmed/20028873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1353
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