Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Inhibitors of poly(ADP-ribose) polymerase (PARP) are in clinical trials for cancer therapy, on the basis of the role of PARP in recruitment of base excision repair (BER) factors to sites of DNA damage. Here we show that PARP inhibition to block BER is toxic to hypoxic cancer cells, in which homology...

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Bibliografiska uppgifter
Huvudupphovsmän: Hegan, Denise Campisi, Lu, Yuhong, Stachelek, Gregory C., Crosby, Meredith E., Bindra, Ranjit S., Glazer, Peter M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836641/
https://ncbi.nlm.nih.gov/pubmed/20133863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904783107
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