Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells

There is an emerging concept that acquired genetic instability in cancer cells can arise from the dysregulation of critical DNA repair pathways due to cell stresses such as inflammation and hypoxia. Here we report that hypoxia specifically down-regulates the expression of RAD51, a key mediator of ho...

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Autori principali: Bindra, Ranjit S., Schaffer, Paul J., Meng, Alice, Woo, Jennifer, Måseide, Kårstein, Roth, Matt E., Lizardi, Paul, Hedley, David W., Bristow, Robert G., Glazer, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
DNA Dynamics and Chromosome Structure
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC516750/
https://ncbi.nlm.nih.gov/pubmed/15367671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8504-8518.2004
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