Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells

There is an emerging concept that acquired genetic instability in cancer cells can arise from the dysregulation of critical DNA repair pathways due to cell stresses such as inflammation and hypoxia. Here we report that hypoxia specifically down-regulates the expression of RAD51, a key mediator of ho...

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Detalhes bibliográficos
Main Authors: Bindra, Ranjit S., Schaffer, Paul J., Meng, Alice, Woo, Jennifer, Måseide, Kårstein, Roth, Matt E., Lizardi, Paul, Hedley, David W., Bristow, Robert G., Glazer, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516750/
https://ncbi.nlm.nih.gov/pubmed/15367671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8504-8518.2004
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