Metnase promotes restart and repair of stalled and collapsed replication forks

Metnase is a human protein with methylase (SET) and nuclease domains that is widely expressed, especially in proliferating tissues. Metnase promotes non-homologous end-joining (NHEJ), and knockdown causes mild hypersensitivity to ionizing radiation. Metnase also promotes plasmid and viral DNA integr...

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Autori principali: De Haro, Leyma P., Wray, Justin, Williamson, Elizabeth A., Durant, Stephen T., Corwin, Lori, Gentry, Amanda C., Osheroff, Neil, Lee, Suk-Hee, Hromas, Robert, Nickoloff, Jac A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943610/
https://ncbi.nlm.nih.gov/pubmed/20457750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq339
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