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Cytokine-Associated Drug Toxicity in Human Hepatocytes Is Associated with Signaling Network Dysregulation
Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of its underlying mechanisms. Findings in animal models have shown that adverse effects of numerous drugs with idios...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943488/ https://ncbi.nlm.nih.gov/pubmed/20361094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b926287c |
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