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Cytokine-Associated Drug Toxicity in Human Hepatocytes Is Associated with Signaling Network Dysregulation

Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of its underlying mechanisms. Findings in animal models have shown that adverse effects of numerous drugs with idios...

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Autors principals: Cosgrove, Benjamin D., Alexopoulos, Leonidas G., Hang, Ta-chun, Hendriks, Bart S., Sorger, Peter K., Griffith, Linda G., Lauffenburger, Douglas A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943488/
https://ncbi.nlm.nih.gov/pubmed/20361094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b926287c
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