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ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of Pseudomonas Exotoxin-based proteins to the cell cytosol

Pseudomonas exotoxin (PE)-based immunotoxins (antibody-toxin fusion proteins) have achieved frequent complete remissions in patients with hairy cell leukemia but far fewer objective responses in other cancers. To address possible mechanisms of resistance, we investigated immunotoxin activity in a mo...

詳細記述

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書誌詳細
主要な著者: Traini, Roberta, Ben-Josef, Gal, Pastrana, Diana V., Moskatel, Elizabeth, Sharma, Ashima K., Antignani, Antonella, FitzGerald, David J.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943340/
https://ncbi.nlm.nih.gov/pubmed/20587662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0257
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