Nuclear Role of WASp in the Pathogenesis of Dysregulated T(H)1 Immunity in Human Wiskott-Aldrich Syndrome

The clinical symptomatology in the X-linked Wiskott-Aldrich syndrome (WAS), a combined immunodeficiency and autoimmune disease resulting from WAS protein (WASp) deficiency, reflects the underlying coexistence of an impaired T helper 1 (T(H)1) immunity alongside intact T(H)2 immunity. This suggests a...

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Detalhes bibliográficos
Main Authors: Taylor, Matthew D., Sadhukhan, Sanjoy, Kottangada, Ponnappa, Ramgopal, Archana, Sarkar, Koustav, D’Silva, Sheryl, Selvakumar, Annamalai, Candotti, Fabio, Vyas, Yatin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943146/
https://ncbi.nlm.nih.gov/pubmed/20574068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000813
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