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R-loops cause genomic instability in Wiskott-Aldrich syndrome T(helper) lymphocytes
BACKGROUND: Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT), and X-linked neutropenia (XLN), caused by WAS mutations affecting WASp expression or activity, manifest in immunodeficiency, autoimmunity, genomic-instability, and lymphoid-cancer. WASp supports filamentous-actin formation...
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| 出版年: | J Allergy Clin Immunol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6003829/ https://ncbi.nlm.nih.gov/pubmed/29248492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.11.023 |
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