R-loops cause genomic instability in Wiskott-Aldrich syndrome T(helper) lymphocytes

BACKGROUND: Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT), and X-linked neutropenia (XLN), caused by WAS mutations affecting WASp expression or activity, manifest in immunodeficiency, autoimmunity, genomic-instability, and lymphoid-cancer. WASp supports filamentous-actin formation...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Sarkar, Koustav, Han, Seong-Su, Wen, Kuo-Kuang, Ochs, Hans D., Dupré, Loïc, Seidman, Michael M., Vyas, Yatin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003829/
https://ncbi.nlm.nih.gov/pubmed/29248492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.11.023
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