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Nuclear Role of WASp in Gene Transcription is Uncoupled from its ARP2/3-Dependent Cytoplasmic Role in Actin Polymerization
Defects in Wiskott-Aldrich Syndrome protein (WASp) underlie development of WAS, an X-linked immunodeficiency and autoimmunity disorder of childhood. Nucleation-promoting factors (NPFs) of the WASp-family generate F-actin in the cytosol via the VCA-domain and support RNA polymerase II-dependent trans...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137324/ https://ncbi.nlm.nih.gov/pubmed/24872192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302923 |
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