Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

The forkhead-box protein P3 (Foxp3) is a key transcription factor for the development and suppressive activity of regulatory T cells (Tregs), a T cell subset critically involved in the maintenance of self-tolerance and prevention of over-shooting immune responses. However, the transcriptional regula...

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Main Authors: Polansky, Julia K., Schreiber, Lisa, Thelemann, Christoph, Ludwig, Leif, Krüger, Melanie, Baumgrass, Ria, Cording, Sascha, Floess, Stefan, Hamann, Alf, Huehn, Jochen
Formato: Artigo
Idioma:Inglês
Publicado: Springer-Verlag 2010
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943068/
https://ncbi.nlm.nih.gov/pubmed/20574810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-010-0642-1
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