Genome instability due to ribonucleotide incorporation into DNA

Maintaining the chemical identity of DNA depends on ribonucleotide exclusion by DNA polymerases. However, ribonucleotide exclusion during DNA synthesis in vitro is imperfect. To determine if ribonucleotides are incorporated during DNA replication in vivo, we substituted leucine or glycine for an act...

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Autores principales: Nick McElhinny, Stephanie A., Kumar, Dinesh, Clark, Alan B., Watt, Danielle L., Watts, Brian E., Lundström, Else-Britt, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942972/
https://ncbi.nlm.nih.gov/pubmed/20729855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.424
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