Genome instability due to ribonucleotide incorporation into DNA

Maintaining the chemical identity of DNA depends on ribonucleotide exclusion by DNA polymerases. However, ribonucleotide exclusion during DNA synthesis in vitro is imperfect. To determine if ribonucleotides are incorporated during DNA replication in vivo, we substituted leucine or glycine for an act...

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Autors principals: Nick McElhinny, Stephanie A., Kumar, Dinesh, Clark, Alan B., Watt, Danielle L., Watts, Brian E., Lundström, Else-Britt, Johansson, Erik, Chabes, Andrei, Kunkel, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942972/
https://ncbi.nlm.nih.gov/pubmed/20729855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.424
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