Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ε

We have investigated the ability of the 3′ exonuclease activity of S. cerevisiae DNA polymerase ε (Pol ε) to proofread newly inserted ribonucleotides (rNMPs). During DNA synthesis in vitro, Pol ε proofreads ribonucleotides with apparent efficiencies that vary from none at some locations to more than...

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Main Authors: Williams, Jessica S., Clausen, Anders R., Nick McElhinny, Stephanie A., Watts, Brian E., Johansson, Erik, Kunkel, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407341/
https://ncbi.nlm.nih.gov/pubmed/22682724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.05.004
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