Distinct Epigenetic Domains Separated by a CTCF Bound Insulator between the Tandem Genes, BLU and RASSF1A

BACKGROUND: Tumor suppressor gene (TSG) RASSF1A and candidate TSG BLU are two tandem head-to-tail genes located at 3p21.3. We hypothesized that there may be a concordance on their gene expression and promoter methylation status. If not, then there may be an insulator located between RASSF1A and BLU...

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Main Authors: Chang, Jer-Wei, Hsu, Han-Shui, Ni, Huey-Juin, Chuang, Ching-Ting, Hsiung, Chi-Hui, Huang, Tim H., Wang, Yi-Ching
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942851/
https://ncbi.nlm.nih.gov/pubmed/20877461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012847
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