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CTCF: from insulators to alternative splicing regulation
The zinc-finger DNA-binding protein CTCF has been known for being a constituent of insulators. A recent paper in Nature reports an unforeseen intragenic role for CTCF that links DNA methylation with alternative splicing. By binding to its target DNA site placed within an alternative exon, CTCF creat...
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| Format: | Artigo |
| Jezik: | Inglês |
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Nature Publishing Group
2012
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3292291/ https://ncbi.nlm.nih.gov/pubmed/22310241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.22 |
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