Código QR (código de barras bidimensional)

Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.

Prevention of red cell K+ and water loss is a therapeutic strategy for sickle cell disease. We have investigated in vitro and in vivo the effects of clotrimazole (CLT) and miconazole (MIC) on transgenic mice red cells expressing hemoglobin SAD. CLT blocked the Gardos channel (ID50 75 +/- 22 nM; n =...

ver descrição completa

Na minha lista:
Publicado no:J Clin Invest
Principais autores: De Franceschi, L, Saadane, N, Trudel, M, Alper, S L, Brugnara, C, Beuzard, Y
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294212/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117149
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registros relacionados