Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.

Prevention of red cell K+ and water loss is a therapeutic strategy for sickle cell disease. We have investigated in vitro and in vivo the effects of clotrimazole (CLT) and miconazole (MIC) on transgenic mice red cells expressing hemoglobin SAD. CLT blocked the Gardos channel (ID50 75 +/- 22 nM; n =...

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Pubblicato in:	J Clin Invest
Autori principali:	De Franceschi, L, Saadane, N, Trudel, M, Alper, S L, Brugnara, C, Beuzard, Y
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117149
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