Cathepsin L inactivates human trypsinogen whereas cathepsin L deletion reduces the severity of pancreatitis in mice

BACKGROUND & AIMS: Acute pancreatitis is characterized by an activation cascade of digestive enzymes in the pancreas. The first of these, trypsinogen, can be converted to active trypsin by the peptidase cathepsin B (CTSB). We investigated whether cathepsin L (CTSL), the second most abundant lyso...

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Main Authors: Wartmann, Thomas, Mayerle, Julia, Kähne, Thilo, Sahin-Tóth, Miklós, Ruthenbürger, Manuel, Matthias, Rainer, Kruse, Anne, Reinheckel, Thomas, Peters, Christoph, Weiss, F. Ulrich, Sendler, Matthias, Hans-Lippert, Schulz, Hans-Ulrich, Aghdassi, Ali, Dummer, Annegret, Teller, Steffen, Halangk, Walter, Lerch, Markus M.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941736/
https://ncbi.nlm.nih.gov/pubmed/19900452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.10.048
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