Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis

Pancreatitis is associated with premature activation of digestive proteases in the pancreas. The lysosomal hydrolase cathepsin B (CTSB) is a known activator of trypsinogen, and its deletion reduces disease severity in experimental pancreatitis. Here we studied the activation mechanism and subcellula...

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Vydáno v:J Biol Chem
Hlavní autoři: Sendler, Matthias, Maertin, Sandrina, John, Daniel, Persike, Maria, Weiss, F. Ulrich, Krüger, Burkhard, Wartmann, Thomas, Wagh, Preshit, Halangk, Walter, Schaschke, Norbert, Mayerle, Julia, Lerch, Markus M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938190/
https://ncbi.nlm.nih.gov/pubmed/27226576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718999
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