Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response. We investigated how these processes interact during severe pancreatitis in mice. METHODS: Pancreatitis was...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Sendler, Matthias, Weiss, Frank-Ulrich, Golchert, Janine, Homuth, Georg, van den Brandt, Cindy, Mahajan, Ujjwal M., Partecke, Lars-Ivo, Döring, Paula, Gukovsky, Ilya, Gukovskaya, Anna S., Wagh, Preshit R., Lerch, Markus M., Mayerle, Julia
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6663074/
https://ncbi.nlm.nih.gov/pubmed/29079517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.10.018
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