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Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice
BACKGROUND & AIMS: Acute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response. We investigated how these processes interact during severe pancreatitis in mice. METHODS: Pancreatitis was...
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| izdano v: | Gastroenterology |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6663074/ https://ncbi.nlm.nih.gov/pubmed/29079517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.10.018 |
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